New Study Explains Why Painkillers Harm Your Heart
Ibuprofen and other non-steroidal anti-inflammatory drugs have long been associated with heart disease. But why? In the recent investigation by scientists from University of California, Davis, they explain why these drugs can harm heart tissue.
They found that pain killers harm heart tissue in several ways. First, they attack the mitochondria, reducing the cardiac cell’s ability to produce energy. Next, it also causes the production of oxygen species which puts a strain on the heart cells and is associated with many diseases including heart disease. Third, it impair the cardiac cell’s proteasome, the mechanism for degrading harmful proteins, leading to toxic build up and eventually to the death of cardiac cells.
"We knew these non-steroidal anti-inflammatories had negative side effects for heart disease and stroke risk,” said corresponding author Aldrin Gomes, a UC Davis associate professor of Neurobiology, Physiology and Behaviour. "But now we have an idea of some of the mechanisms behind it."
Researchers suggest taking vitamin C prior to painkiller to prevent cardiac cell death without interfering with the drug’s ability to provide pain relief. They also add rubbing the anti-inflammatory topically onto the pained area can be effective without exposing the entire body to increased cardiovascular risk. Yet he advised caution when using NSAIDs either topically or orally.
Natural Remedies
Instead of pharmaceutical drugs, there are natural remedies that we can turn to for managing pain. Some Turmeric, for instance, has been found to help people with osteoarthritis because it helps relieve inflammation. Cloves, on the other hand, may help relieve the pain associated with headaches, arthritic inflammation, and toothaches. Acupuncture is another remedy. It works by balancing the body’s natural energy pathways. It results to an increase in the production of the ‘feel good’ hormone called serotonin and reduction of pain.
Source of this article:
Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells
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