Ground-breaking Research Explains Biological Cause of Parkinson’s disease
Scientists unravelled another research breakthrough which could explain how Parkinson’s disease occurs and develops.
The study, carried out by the UQ’s Institute for Molecular Bioscience, showed that Parkinson’s disease may be caused by a mutation which interrupts the traffic of materials within neurons and allows waste products to accumulate. This is the first time that a biological process was determined which gives light to the understanding of the disease. Previously, Parkinson’s was linked to dysfunctions in retromer - a protein machine responsible for transporting biological material within a cell.
Parkinson’s disease is a progressive disorder of the nervous system which affects a person’s mobility. It is chiefly affecting middle-aged and elderly people, and until now, it doesn’t have a cure yet.
"It has been identified that one of these proteins (Vps35) is mutated in some Parkinson’s patients, which creates congestion in the transport network inside cells," says Associate Professor Rohan Teasdale.
"As a result, it appears that the workers responsible for recycling material within these neurons are not getting to their correct work place and without their assistance the cells within the brain cannot rid themselves of waste materials, which increases the likelihood of cell death.”
Cell death then leads to Parkinson’s symptoms like tremors and muscle stiffness, Prof Teasdale added.
In their study, the researchers expanded the transport network so the neurons could get rid themselves of waste. They theorised that doing this can drastically slow down the progression of Parkinson’s disease. Prof Teasdale added that this principle can be applied in nearly 50 other disorders that are caused by the build-up of waste materials within cells.
The new findings were published in the Journal of Biological Chemistry.
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